- claim_text
Layer 2/3 cortical pyramidal neurons distribute axons principally within the cerebral cortex, while layer 5 pyramidal tract neurons project ipsilaterally within the cortex and to subcortical targets, and layer 5 inter-telencephalic neurons project bilaterally to the cerebral cortex and striatum.
- raw_fields
{
"n": 0,
"doi": "10.1002/jnr.23978",
"claim": "Layer 2/3 cortical pyramidal neurons distribute axons principally within the cerebral cortex, while layer 5 pyramidal tract neurons project ipsilaterally within the cortex and to subcortical targets, and layer 5 inter-telencephalic neurons project bilaterally to the cerebral cortex and striatum.",
"cite_key": "Gerfen2018",
"evidence": "Review of neuroanatomical tracing studies using GENSAT BAC-Cre transgenic mouse lines combined with AAV-GFP anterograde tracing and rabies virus retrograde tracing to characterize long-distance projections of cortical pyramidal neuron subtypes.",
"effect_size": "",
"text_access": "fulltext",
"study_system": "mouse cerebral cortex, review of neuroanatomical tracing and neurophysiology",
"argument_role": "supporting",
"replication_status": "consistent_with_prior",
"claim_source_sentence": "As described above, cortical pyramidal neurons in layers 2 and 3 give rise to axonal projections distributed within the cerebral cortex, while layer 5 is composed of two main subtypes, inter-telencephalic neurons (IT) providing projections bilaterally to the cerebral cortex and striatum, and pyramidal tract neurons (PT) that provide inputs ipsilaterally to the cortex and subcortical structures.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": ""
}- source_refs
[
"paper:paper-b0b284f0f8b1"
]
- source_span
As described above, cortical pyramidal neurons in layers 2 and 3 give rise to axonal projections distributed within the cerebral cortex, while layer 5 is composed of two main subtypes, inter-telencephalic neurons (IT) providing projections bilaterally to the cerebral cortex and striatum, and pyramidal tract neurons (PT) that provide inputs ipsilaterally to the cortex and subcortical structures.
- evidence_refs
[
{
"ref": "paper:paper-b0b284f0f8b1"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Review of neuroanatomical tracing studies using GENSAT BAC-Cre transgenic mouse lines combined with AAV-GFP anterograde tracing and rabies virus retrograde tracing to characterize long-distance projections of cortical pyramidal neuron subtypes.