In mouse V1, cortico-cortical projection neurons to eleven higher visual areas…

In mouse V1, cortico-cortical projection neurons to eleven higher visual areas develop their target specificity via spatiotemporally staggered axon extension and pruning programs aligned with target position along the medial-lateral axis — refining the dichotomy between 'exuberant growth + pruning' and 'directed targeting' models of cortico-cortical wiring development.

{
  "n": 0,
  "doi": "10.1101/2025.11.03.686379",
  "claim": "In mouse V1, cortico-cortical projection neurons to eleven higher visual areas develop their target specificity via spatiotemporally staggered axon extension and pruning programs aligned with target position along the medial-lateral axis — refining the dichotomy between 'exuberant growth + pruning' and 'directed targeting' models of cortico-cortical wiring development.",
  "cite_key": "Jacobs2025",
  "evidence": "Postnatal developmental time-series in mouse V1 mapped with retrograde, anterograde and single-cell tracing onto eleven higher visual areas (HVAs).",
  "effect_size": "Spatiotemporal staggering of axon extension/pruning correlated with target medial-lateral position.",
  "text_access": "abstract_only",
  "study_system": "postnatal mouse V1, multimodal (retrograde + anterograde + single-cell) developmental tracing onto 11 higher visual areas",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "We found that V1→HVA connectivity develops via spatiotemporally staggered axon extension and pruning programs, aligned with target position along the medial-lateral axis.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1101/2025.07.17.665445"
  ],
  "effect_size_source_sentence": null
}

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