Optomapping of 30,454 candidate inputs in mouse V1 reveals 1,790 excitatory inp…

Optomapping of 30,454 candidate inputs in mouse V1 reveals 1,790 excitatory inputs distributed across cell types with log-normal synaptic-efficacy distribution; pyramidal-cell input reproduces the canonical L4→L2/3→L5 microcircuit while basket-cell excitation concentrates in L5 and Martinotti-cell excitation dominates in L2/3.

{
  "n": 1790,
  "doi": "10.1016/j.xinn.2024.100735",
  "claim": "Optomapping of 30,454 candidate inputs in mouse V1 reveals 1,790 excitatory inputs distributed across cell types with log-normal synaptic-efficacy distribution; pyramidal-cell input reproduces the canonical L4→L2/3→L5 microcircuit while basket-cell excitation concentrates in L5 and Martinotti-cell excitation dominates in L2/3.",
  "cite_key": "Chou2025",
  "evidence": "Two-photon optogenetic 'optomapping', ~100x faster than paired patch, in mouse V1 across cell types.",
  "effect_size": "30,454 candidate inputs; 1,790 excitatory inputs; log-normal efficacy distribution.",
  "text_access": "abstract_only",
  "study_system": "mouse V1; two-photon 'optomapping' optogenetic input mapping",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "In mouse primary visual cortex (V1), we optomapped 30,454 candidate inputs to reveal 1,790 excitatory inputs to pyramidal, basket, and Martinotti cells. Across these cell types, log-normal distribution of synaptic efficacies emerged as a principle. For pyramidal cells, optomapping reproduced the canonical circuit but unexpectedly uncovered that the excitation of basket cells concentrated to layer 5 and that of Martinotti cells dominated in layer 2/3.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.7554/eLife.71103",
    "10.1038/s41586-025-08840-3"
  ],
  "effect_size_source_sentence": "In mouse primary visual cortex (V1), we optomapped 30,454 candidate inputs to reveal 1,790 excitatory inputs to pyramidal, basket, and Martinotti cells."
}

[
  "paper:paper-20192df165b8"
]

In mouse primary visual cortex (V1), we optomapped 30,454 candidate inputs to reveal 1,790 excitatory inputs to pyramidal, basket, and Martinotti cells. Across these cell types, log-normal distribution of synaptic efficacies emerged as a principle. For pyramidal cells, optomapping reproduced the canonical circuit but unexpectedly uncovered that the excitation of basket cells concentrated to layer 5 and that of Marti...

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