Touch-evoked translaminar dynamics in awake mouse barrel cortex are organized a…

Touch-evoked translaminar dynamics in awake mouse barrel cortex are organized as a fast early component followed by a sparse late wave in L2/3 aligned to L5 apical dendritic Ca2+ events — a translaminar 'spacetime code' that depends on cortical feedback and is reconciled by an inhibition-stabilized balanced-state model.

{
  "n": 0,
  "doi": "10.1126/sciadv.adr4038",
  "claim": "Touch-evoked translaminar dynamics in awake mouse barrel cortex are organized as a fast early component followed by a sparse late wave in L2/3 aligned to L5 apical dendritic Ca2+ events — a translaminar 'spacetime code' that depends on cortical feedback and is reconciled by an inhibition-stabilized balanced-state model.",
  "cite_key": "Gonzales2025",
  "evidence": "Simultaneous NeuroGrid electrophysiology + 2P calcium imaging in awake mouse barrel cortex during whisker touch.",
  "effect_size": "Late translaminar wave aligned to L5 apical dendritic Ca2+ events; modulated by cortical feedback.",
  "text_access": "abstract_only",
  "study_system": "awake mouse barrel cortex; simultaneous electrophysiology + 2P calcium imaging through transparent NeuroGrids",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We found that the late wave feature was (i) modulated by motor feedback, (ii) differentially engaged a sparse ensemble reactivation pattern across layer 2/3, which a balanced-state network model reconciled via feedback-induced inhibitory stabilization, and (iii) aligned to regenerative layer 5 apical dendritic Caevents.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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  "paper:paper-859009465eec"
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We found that the late wave feature was (i) modulated by motor feedback, (ii) differentially engaged a sparse ensemble reactivation pattern across layer 2/3, which a balanced-state network model reconciled via feedback-induced inhibitory stabilization, and (iii) aligned to regenerative layer 5 apical dendritic Caevents.

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