In mouse barrel cortex, an axonal calcium-imaging study of vM1→vS1 L1 feedback…

In mouse barrel cortex, an axonal calcium-imaging study of vM1→vS1 L1 feedback projections shows that individual L1 axons carry whisker movement, touch and other behavioural variables, and a subpopulation persists for seconds after touch encoding object location — providing direct evidence for the functional role of L1 apical-dendrite-targeting feedback excitation.

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  "doi": "10.1038/nature11321",
  "claim": "In mouse barrel cortex, an axonal calcium-imaging study of vM1→vS1 L1 feedback projections shows that individual L1 axons carry whisker movement, touch and other behavioural variables, and a subpopulation persists for seconds after touch encoding object location — providing direct evidence for the functional role of L1 apical-dendrite-targeting feedback excitation.",
  "cite_key": "Petreanu2012",
  "evidence": "Two-photon axonal calcium imaging of vM1→vS1 L1 afferents in mice during whisker-dependent object localization.",
  "effect_size": "Persistent L1 axonal signals encode object location for seconds after touch.",
  "text_access": "abstract_only",
  "study_system": "mouse barrel cortex; in vivo axonal 2P imaging of vM1→vS1 L1 feedback afferents",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Spatially intermingled individual axons represent whisker movements, touch and other behavioural features. In a subpopulation of axons, activity depends on object location and persists for seconds after touch.",
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  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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