In mouse, axons of vibrissal motor cortex (vM1) projecting to vibrissal somatos…

In mouse, axons of vibrissal motor cortex (vM1) projecting to vibrissal somatosensory cortex (vS1) layer 1 carry whisker-position signals that combine with whisker-touch signals in vS1, demonstrating that long-range cortico-cortical M1→S1 feedback to L1 transmits behaviorally relevant contextual information to tuft dendrites of pyramidal neurons.

{
  "n": null,
  "doi": "10.1038/nature11321",
  "claim": "In mouse, axons of vibrissal motor cortex (vM1) projecting to vibrissal somatosensory cortex (vS1) layer 1 carry whisker-position signals that combine with whisker-touch signals in vS1, demonstrating that long-range cortico-cortical M1→S1 feedback to L1 transmits behaviorally relevant contextual information to tuft dendrites of pyramidal neurons.",
  "cite_key": "Petreanu2012",
  "evidence": "Two-photon calcium imaging of vM1 axons in L1 of vS1 in mice palpating objects with whiskers; behavioral object-localization task.",
  "effect_size": "vM1→vS1 L1 axons encode whisker position; vS1 receives convergent touch and motor-position signals.",
  "text_access": "abstract_only",
  "study_system": "Awake mice; two-photon axonal imaging of vM1 in vS1 L1.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "When mice palpate objects with their whiskers to localize object features, whisker touch excites vS1, while whisker position is signaled by vM1 axons in L1 of vS1.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1016/j.celrep.2018.04.115"
  ],
  "effect_size_source_sentence": "L1 input is thought to provide 'contextual' information, but the signals transmitted by L1 feedback remain uncharacterized."
}

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