- claim_text
Mediodorsal thalamic input does not relay categorical rule information to mouse prefrontal cortex; instead it amplifies local PFC connectivity, allowing rule-specific neural sequences to emerge and to sustain rule representations, with enhancing MD excitability improving rule-specific PFC coding and behavioural performance.
- raw_fields
{
"n": 0,
"doi": "10.1038/nature22073",
"claim": "Mediodorsal thalamic input does not relay categorical rule information to mouse prefrontal cortex; instead it amplifies local PFC connectivity, allowing rule-specific neural sequences to emerge and to sustain rule representations, with enhancing MD excitability improving rule-specific PFC coding and behavioural performance.",
"cite_key": "Schmitt2017",
"evidence": "Broadly enhancing PFC excitability diminishes rule specificity and behavioural performance, whereas enhancing mediodorsal excitability improves both.",
"effect_size": "",
"text_access": "fulltext",
"study_system": "mouse mediodorsal thalamus → prefrontal cortex; optogenetic/chemogenetic MD perturbation and PFC ensemble recordings during a rule-guided attention task",
"argument_role": "supporting",
"replication_status": "single_lab",
"claim_source_sentence": "Specifically, mediodorsal input amplifies local PFC connectivity, enabling rule-specific neural sequences to emerge and thereby maintain rule representations.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-1eecf1966d88"
]
- evidence_refs
[
{
"ref": "paper:paper-1eecf1966d88"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}