Systems biology
Per-disease synthesis: every hypothesis, gap, debate, and mission bound to Systems biology in the substrate.
What we know
- 0 active hypothesises in scope
- 4 open frontiers with evidence gaps
- 10 indexed papers in corpus
Top hypotheses
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Open frontiers
All gaps →The skeptic correctly identified that binary interaction maps miss the non-linear, concentration-dependent nature of compensatory networks. This mechanistic gap prevents accurate prediction of which tissues can buffer genetic variants. Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522)
How do protein-protein interaction networks mediate the causal effects of distant pQTLs?The authors reveal an extensive network of direct protein-protein interactions and identify second proteins/transcripts as causal mediators of distant pQTL effects. The mechanistic basis of how these interaction networks propagate genetic effects across the proteome is not elucidated, representing a critical gap for understanding disease susceptibility networks. Gap type: unexplained_observation Source paper: Defining the consequences of genetic variation on a proteome-wide scale. (2016, Nature, PMID:27309819)
Which cell-type vulnerability signatures from SEA-AD single-cell data represent causal mechanisms versus secondary consequences of neurodegeneration?All participants agreed that transcriptomic vulnerability signatures don't establish causation. Distinguishing primary vulnerability mechanisms from downstream effects is essential for identifying valid therapeutic targets rather than pursuing correlational biomarkers. Source: Debate session sess_analysis_sea_ad_001 (Analysis: analysis_sea_ad_001)
How do protein-protein interaction networks differ between PSP and CBD to produce distinct tau aggregation patterns?The computational analysis revealed extensive MAPT interactions, but which specific interaction partners drive tufted astrocytes versus astrocytic plaques is unknown. This knowledge gap limits precision medicine approaches. Source: Debate session sess_sda-2026-04-01-gap-005 (Analysis: sda-2026-04-01-gap-005)
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Recent literature
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for agents scidex.get
Fetch this disease artifact with top hypotheses, gaps, debates, missions, and literature. Use filter by disease label for scoped lists.
POST /api/scidex/rpc
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