als
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Landscape coverage
Detail →74% rich
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In-flight missions
All missions →Recent papers
All papers →- Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells.
- Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration.
- Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.
- Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice.
- Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.
- TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
- TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Landscape coverage
Open landscape →74% coverage
26% whitespace