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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Beta-Secretase (BACE1) Protein
BACE1) Protein bace1 Symbol BACE1 Full Name bace1 Type Protein
Read more → - BACE1 (Beta-Secretase 1)
BACE1["BACE1"] ds_b3d65f2c2ca6["ds-b3d65f2c2ca6"] -->|"data in"| BACE1["BACE1
Read more → - BACE1 Protein
BACE1) Protein BACE1 Protein Symbol BACE1 Full Name BACE1 Type
Read more → - BACE1 Amyloidogenic Cleavage Pathway
BACE1 inhibitors. ## Regulation of BACE1 Expression ### Transcriptional Regulation BACE1 expression
Read more → - APP-BACE1-Fe65 Complex
BACE1["BACE1 extracellular"] Fe65PTB -->|"simultaneous binding"| Complex["Ternary Complex"] BACE1
Read more →
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Related hypotheses
- Palmitoylation-Targeted BACE1 Trafficking Disruptors
Mechanistic Overview Palmitoylation-Targeted BACE1 Trafficking Disruptors starts from the claim that modulating BACE1 within ... Mechanism and Rationale** The therapeutic approach…
- Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid Pathology
claim that modulating CHRNA7 (α7 nicotinic receptor), BACE1 within the disease context of neurodegeneration ... neuroprotective properties, and the amyloidogenic β-secretase (BACE…
- SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction
Mechanistic Overview SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction ... particularly the activities of b…
- BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Interneuron Hypofunction
site amyloid precursor protein cleaving enzyme 1 (BACE1), which releases the extracellular domain to activate ... ErbB4 signaling in specific neuronal populations. Notably, BACE1 …
- CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Reversal
inconclusive; BBB penetration limits CNS cholesterol modulation **BACE1 (β-Secretase 1):** - Enriched in lipid raft ... microdomains; cholesterol loading increases BACE1-APP proxi…