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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- BECN1 Protein (Beclin-1)
BECN1["BECN1"] AUTOPHAGY["AUTOPHAGY"] -->|"activates"| BECN1["BECN1"] AMPK["AMPK"] -->|"activates
Read more → - BECN1 Gene
BECN1["BECN1"] -->|"associated with"| PIK3C3["PIK3C3"] BECN1["BECN1"] -->|"activates"| autophagy
Read more → - becn1-autophagy-initiation-neurodegeneration-causal-chain
BECN1 ### Therapeutic Implications #### Direct BECN1 Restoration | Strategy | Approach | Status | |----------|---------|--------| | AAV-BECN1
Read more → - Beclin-1 Protein
BECN1 -->|"associated with"| PIK3C3 BECN1 -->|"activates"| autophagy BECN1 -->|"associated with
Read more → - Beclin-1 Protein
BECN1 mRNA and protein in AD brain - **Genetic association**: BECN1
Read more →
Graph neighborhood (30 nodes · 175 edges)
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Related hypotheses
- SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via Autophagosome-Lysosome Fusion Dysfunction
starts from the claim that modulating SGMS1, BECN1 within the disease context of neurodegeneration ... autophagosome-lysosome membrane fusion. Additionally, beclin-1 (BECN1), the …
- Transcriptional Autophagy-Lysosome Coupling
autophagy genes including ATG5, ATG7, ATG12, LC3B, BECN1, SQSTM1/p62, ULK1 - Increases autophagosome formation and autophagy ... complex promotes LC3 lipidation and membrane expan…
- hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for miR-6361 Sequestration
like autophagy activating kinase 1) and BECN1 (beclin-1) mRNAs. Both ULK1 and BECN1 ... FIP200 complex that initiates autophagosome formation, while BECN1 forms the core of the cl…
- Circadian Clock-Autophagy Synchronization
regulators such as ATG5, ATG7, LC3B, and BECN1. The molecular synchronization between circadian rhythms ... autophagy gene expression (ATG5, ATG7, LC3B, BECN1), accelerating neuro…
- VCP-Mediated Autophagy Enhancement
Supporting the Hypothesis 1. VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy. [PMID ... Supporting the Hypothesis 1. VCP/p97 UFMylation stabilizes …