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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- CD38 Molecule (CD38)
CD38["CD38 Molecule CD38"] -->|"associated with"| neurodegeneration["neurodegeneration"] CD38["CD38
Read more → - CD38 Inhibitor Therapy for Neurodegeneration
CD38 Biology and NAD+ Regulation ### CD38 Enzymatic Activity CD38 catalyzes
Read more → - CD38 Inhibition + NAD+ Precursor Synergy for Neuroprotection
CD38 Biology CD38 is a transmembrane glycoprotein that functions as an ecto
Read more → - NAD+ Metabolism in Neurodegeneration
CD38["CD38"] CD38 -.->|"downregulates"| NAD_ style Blood_Brain_Barrier_Damage
Read more → - NAD Signaling in Neurodegeneration
CD38 and CD157 metabolize NAD+ into signaling metabolites (including cADPR
Read more →
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Related hypotheses
- Senescence-Activated NAD+ Depletion Rescue
hypothesis centers on the enzymatic activity of CD38, a multifunctional ectoenzyme that functions ... primary NAD+ glycohydrolase in mammalian tissues. CD38 exhibits dual enzymati…
- CD38 Inhibition to Prevent NAD+ Depletion and Restore Cellular Bioenergetics in Age-Related Metabolic Dysfunction
This hypothesis proposes that targeting CD38, the primary NAD+-consuming enzyme, represents a more direct ... metabolic dysfunction than NAD+ precursor supplementation. CD38 expre…
- CD38 Inhibition to Preserve NAD+ Pools and Prevent PARP1-Mediated Metabolic Dysfunction
This hypothesis proposes that CD38, the primary NAD+-consuming enzyme, represents a more effective therapeutic ... ribose) polymerase (PARP1)-driven metabolic catastrophe. CD38 ac…
- Astrocyte CD38-erk Mapk signaling controls mitochondrial transfer to neurons via Tnt-mediated vesicle trafficking
Under neurodegenerative stress, astrocytes upregulate CD38, which triggers Erk MAPK signaling to promote tunneling nanotube ... bioenergetics and reducing apoptosis. Disruption of…
- CD38 Inhibition for NAD+ Restoration and Microglial Senescence Prevention
risk. The Expert identifies a fatal flaw: CD38 is predominantly expressed in peripheral immune cells ... perivascular macrophage infiltration rather than intrinsic microglial CD38…