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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- CGAS Gene
CGAS["CGAS"] DNA["DNA"] -->|"activates"| CGAS["CGAS"] CYTOKINES["CYTOKINES"] -->|"activates
Read more → - cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease
cGAS["cGAS"] dsDNA["dsDNA"] -->|"activates"| cGAS["cGAS"] cytosolic_DNA["cytosolic
Read more → - cGAS-STING Signaling in Parkinson's Disease
cGAS + DNA → cGAS-DNA complex - cGAS-DNA complex catalyzes: 2 ATP + 2 GTP → cGAMP
Read more → - DNA Sensing Pathways in Neurodegeneration
cGAS Inhibitors - **RU.521**: Selective cGAS inhibitor - **Anacardic acid**: cGAS inhibitor
Read more → - cGAS-STING Pathway in Neurodegeneration
cGAS_Activation["cGAS Activation"] B1["Cytosolic dsDNA"] B2["cGAS Binding
Read more →
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Related hypotheses
- Basal cGAS Derepression as Stratification Biomarker
Mechanistic Overview Basal cGAS Derepression as Stratification Biomarker starts from the claim that modulating cGAS ... promoter (CGAS), DNMT1, H3K9me3/Polycomb complex within the…
- cGAS-STING Senescence Circuit Disruption
Rationale The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway represents ... molecular architecture of this pathway involves cGAS (encoded by MB…
- Chronic cGAS/STING Hyperactivation Drives Progressive Neurodegeneration Through Sustained Type I Interferon Signaling
Signaling starts from the claim that modulating cGAS (CGAS) / STING (TMEM173) / IFNAR1/2 within the disease ... Signaling starts from the claim that modulating cGAS (CGAS) / STING…
- Senescent Cell Mitochondrial DNA Release
description reads: "**Molecular Mechanism and Rationale** The cGAS-STING pathway represents a critical innate immune ... that activates the cyclic GMP-AMP synthase (cGAS). Upon bi…
- STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-I Feedback Looping
driven by mitochondrial DNA leakage activating the cGAS-STING pathway, which establishes a chronic type ... TMEM173 (STING)` and the pathway label is `cGAS-STING innate immune sig…