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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- HSP90 Protein (Heat Shock Protein 90)
HSP90["HSP90"] SFRP1["SFRP1"] HSP90 -->|"binds"| SFRP1 GPX4["GPX4"] HSP90
Read more → - Expand Hsp90 content
hsp90_protein["Expand Hsp90 content"] style entities_hsp90_protein fill
Read more → - Heat Shock Protein Response Pathway in Neurodegeneration
Hsp90 complexes. Upon stress, misfolded proteins sequester Hsp90, releasing HSF1
Read more → - HSP90AA1 Gene
Hsp90 **Hsp90/Hsp70 organizing protein (HOP)** Bridges Hsp70 and Hsp90 **p23** Stabilizes
Read more → - AHSA2 Gene
Hsp90 + ATP → Hsp90-ATP → ( conformational changes ) → Hsp90-ADP + Pi ``` AHSA2
Read more →
Graph neighborhood (30 nodes · 115 edges)
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Related hypotheses
- HSP90-Tau Disaggregation Complex Enhancement
Mechanistic Overview HSP90-Tau Disaggregation Complex Enhancement starts from the claim that modulating HSP90AA1 within ... process. The original description reads: "## Mechanisti…
- HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism
Activation as SCFA-Mediated Neuroprotective Mechanism ## Enhancing Hsp90 K489 Deacetylation Through Selective HDAC6 Activation ... synuclein oligomers through targeted deacetylat…
- HSP90-Tau Disaggregation Complex Enhancement
Rationale** The heat shock protein 90 (HSP90) chaperone system represents a critical cellular machinery ... control. HSP90AA1, the inducible cytoplasmic isoform of HSP90, exhibit…
- Multi-Chaperone System Co-Activation Prevents Saturation Through Complementary Substrate Recognition
original description reads: "Simultaneous DNAJB1 enhancement plus Hsp90 inhibition creates parallel disaggregation channels via Hsp70 ... Hsp90 machinery co-activation, preventing…
- Amyloidogenic segments undergo conformational templating by HSP90-HSP70 heterocomplex machinery
sequential conformational templating mechanism mediated by HSP90-HSP70 heterocomplexes, where HSP90 serves as the primary ... refolding machinery. This mechanism centers on HSP90'…
Related debates
- Do tau-specific HSP90 conformational states exist that differ from other client protein complexes?
debate hinged on whether HSP90 adopts unique conformations when bound to tau versus other clients