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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- SIRT1 Signaling Pathway in Alzheimer's Disease
SIRT1-7) in mammals, with SIRT1 being the most extensively
Read more → - SIRT1 Protein
SIRT1 -->|"modifies"| PPARGC1A SIRT1 -->|"activates"| gluconeogenic_genes SIRT1 -.->|"inhibits"| NF_kB SIRT1
Read more → - SIRT1 Gene
SIRT1["SIRT1"] NAD["NAD"] -->|"associated with"| SIRT1["SIRT1"] ROS["ROS"] -->|"activates
Read more → - SIRT1 Activators for Parkinson's Disease
SIRT1 SIRT1 deacetylates multiple components of the autophagy machinery[@sirt1
Read more → - sirtuin-dysfunction-parkinsons
SIRT1 | Noradrenergic vulnerability | | Hippocampus | SIRT1 | Cognitive involvement | | Cortex | SIRT1 | Dementia
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Related hypotheses
- SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence
Mechanistic Overview SIRT1 (Sirtuin 1), a class III NAD+-dependent histone deacetylase, functions ... longevity and stress resistance. In healthy microglia, SIRT1 maintains cellu…
- Metabolic Reprogramming to Reverse Senescence
early senescence through coordinated activation of SIRT1, PGC-1α, and NAMPT pathways, representing a paradigm ... cellular recovery in neurodegenerative contexts. ## Mechanistic …
- Nutrient-Sensing Epigenetic Circuit Reactivation
Reactivation starts from the claim that modulating SIRT1 within the disease context of neurodegeneration ... nutrient-sensing epigenetic circuit centered on AMPK-SIRT1-PGC1α repre…
- SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4 Upregulation in Post-CA Brain
Mechanistic Overview SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4 Upregulation ... Brain starts from the claim that mo…
- NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Complement Amplification
Mechanistic Overview NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Complement Amplification starts from ... claim that modulating NAMPT, SIRT1 within the disease context …