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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- VPS34 Protein
VPS34 Protein ## Introduction Vps34 Protein is an important component in the neurobiology
Read more → - tmem9-protein
VPS34 Agonists**: Direct activators of the VPS34 complex that TMEM9
Read more → - PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34)
VPS34) PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34
Read more → - PIK3C3 (VPS34) Protein
VPS34) Protein | Property | Value | |----------|-------| | **Protein Name** | PIK3C3 / VPS34 | | **Gene Symbol
Read more → - becn1-autophagy-initiation-neurodegeneration-causal-chain
VPS34 Kinase Activity Reduced"] C --> D["PI(3)P Production
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Graph neighborhood (3 nodes · 3 edges)
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Related hypotheses
- VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Specific vs. Bulk Autophagy
Mechanistic Overview VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Specific vs. Bulk Autophagy starts from ... process. The original description reads: "## Mechanistic …
- PI3P Generation at Damaged Lysosomes Promotes Membrane Repair
repair. Damaged lysosomes recruit PIK3C3 complex II (VPS34 complex), which generates PtdIns3P (PI3P) specifically ... restoration. Evidence supports damaged lysosome recruitment o…
- Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling
TREM2 activation reduces Beclin-1 association with VPS34 by 60-70% while simultaneously increasing binding
- Transcriptional Autophagy-Lysosome Coupling
membrane expansion - BECN1 (Beclin-1) complex recruits Vps34 lipid kinase for PI3P production - Result
- AMPK Activation to Restore Autophagy and Clear α-Synuclein Aggregates
mTORC1 inhibition) drives lysosome biogenesis; (4) Vps34 lipid kinase activation generates PI3P for autophagosome nucleation