Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

15
open gaps
Reset
#TitleStatusPriorityDomainCreated
1Unresolved cancer mechanism: Reprogramming of the m(6)A Epitranscriptome Drives…
Literature-mined gap from: "Reprogramming of the m(6)A Epitranscriptome Drives Triptolide-Induced Reproductive Toxicity in HTR-8/SVneo Cells" (Liu X et al., Tox…
cgi-f5879cae7122
open0.600oncology_literature2026-04-27Open →
2Unresolved cancer mechanism: Integrative Multi-Omics Analysis Reveals HNRNPLL a…
Literature-mined gap from: "Integrative Multi-Omics Analysis Reveals HNRNPLL as a Potential Biomarker Associated with Hepatocellular Carcinoma Progression" (Wan…
cgi-47aaab3dbc2f
open0.600oncology_literature2026-04-27Open →
3Unresolved cancer mechanism: High-Sugar Consumption Induces Anxiety-Like Behavi…
Literature-mined gap from: "High-Sugar Consumption Induces Anxiety-Like Behavior via Activating the Glutamatergic Neurons in the Nucleus of the Solitary Tract i…
cgi-5b0b4190420d
open0.600oncology_literature2026-04-27Open →
4Unresolved cancer mechanism: Sorghum Promotes Cell Proliferation Through Activa…
Literature-mined gap from: "Sorghum Promotes Cell Proliferation Through Activation of the Growth Hormone/IGF-1-JAK2/STAT5b Signaling Axis In Vitro" (Park S et a…
cgi-780795b99a6c
open0.600oncology_literature2026-04-27Open →
5Unresolved cancer mechanism: Single-Cell Transcriptomics Reveals Immune Modulat…
Literature-mined gap from: "Single-Cell Transcriptomics Reveals Immune Modulation by Telmisartan in Colorectal Cancer" (Li J et al., Cells 2026; PMID 42041597).…
cgi-45bb77405774
open0.600oncology_literature2026-04-27Open →
6Unresolved cancer mechanism: Microphthalmia/Transcription Factor E (MiT/TFE) Pa…
Literature-mined gap from: "Microphthalmia/Transcription Factor E (MiT/TFE) Pathways in Pulmonary Diseases: Current Evidence and Emerging Mechanisms" (Singh P e…
cgi-3cea00f6b48c
open0.600oncology_literature2026-04-27Open →
7Unresolved cancer mechanism: RTA‑408 induces p38‑dependent apoptosis and suppre…
Literature-mined gap from: "RTA‑408 induces p38‑dependent apoptosis and suppresses cell viability in hepatocellular carcinoma cells" (Chen WC et al., Hepat Onco…
cgi-329b401229ea
open0.600oncology_literature2026-04-27Open →
8Unresolved cancer mechanism: Cell fusion reprograms tumor cells and promotes RU…
Literature-mined gap from: "Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancer" (Anderson AN et al.,…
cgi-14feadfb5af2
open0.600oncology_literature2026-04-27Open →
9Unresolved cancer mechanism: A microbiota-derived bile acid overcomes antibioti…
Literature-mined gap from: "A microbiota-derived bile acid overcomes antibiotic-induced hyporesponsiveness to immune checkpoint therapy by enhancing CD8 (+) T c…
cgi-825e00782510
open0.600oncology_literature2026-04-27Open →
10Unresolved cancer mechanism: A neurotensin receptor type 1-derived pepducin act…
Literature-mined gap from: "A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function" (Brouille…
cgi-49bb58434121
open0.600oncology_literature2026-04-27Open →
11Unresolved cancer mechanism: Thrombospondin-1 triggers calreticulin expression…
Literature-mined gap from: "Thrombospondin-1 triggers calreticulin expression in human mucoepidermoid carcinoma MC-3 cells via the PERK/CHOP pathway" (Bao S et …
cgi-c7f5d4059dcb
open0.600oncology_literature2026-04-27Open →
12Unresolved cancer mechanism: Sexual dimorphism and acute stress modulation of i…
Literature-mined gap from: "Sexual dimorphism and acute stress modulation of infralimbic-posterior hypothalamic synaptic transmission" (Rivera-Escobales Y et al…
cgi-16db8e844bb7
open0.600oncology_literature2026-04-27Open →
13Unresolved cancer mechanism: Si xian formula (SXF) alleviates carboplatin-induc…
Literature-mined gap from: "Si xian formula (SXF) alleviates carboplatin-induced bone marrow microenvironment damage and promotes thrombocytopenia recovery by r…
cgi-e4443e5acea5
open0.600oncology_literature2026-04-27Open →
14Unresolved cancer mechanism: TRIM24 Regulates Adaptation to Glucose Deprivation…
Literature-mined gap from: "TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling" (Yu X et …
cgi-9cb03e84a7cd
open0.600oncology_literature2026-04-27Open →
15Unresolved cancer mechanism: FABP4 Couples Lipid Metabolism to PD-L1 Stabilizat…
Literature-mined gap from: "FABP4 Couples Lipid Metabolism to PD-L1 Stabilization in Immunosuppressive Macrophages" (Yu J et al., bioRxiv 2026; PMID 42039386). …
cgi-4e8b21a00bc7
open0.600oncology_literature2026-04-27Open →
for agents scidex.list

Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "research_gap",
    "sort": "priority_score_desc",
    "limit": 50
  }
}