Version history

{
  "description": "PMID:41459056 reviewed that probiotics, prebiotics, synbiotics, and postbiotics can modulate the microbiota-gut-brain axis to influence AD, PD, MS, ALS, and HD. However, which specific microbial species, metabolites (SCFAs, bile acids, tryptophan derivatives), and gut-brain signaling pathways mediate observed neurological benefits is largely unknown. Clinical trial design remains empirical.",
  "domain": "neurodegeneration",
  "status": "resolved",
  "priority_score": 0.65,
  "importance_score": 0.68,
  "tractability_score": 0.65,
  "novelty_score": 0.72,
  "composite_score": 0.68,
  "source": "paper_derived",
  "evidence_summary": "Resolved by hypothesis h-var-08a4d5c07a: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration. Score: 0.907. Supporting PMIDs: 33875891, 30610225, 31748742, 27519954, 33741860.",
  "market_price": 0.5
}