Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/28/2026, 6:45:21 AM
    Content snapshot 
    {
  "description": "PMID:10.1101/2024.10.30.621160 identified retinal microglia-derived S100A9 activating NLRP3 inflammasome in obese pig retina. S100A9 is also elevated in AD brains. Whether retinal S100A9-NLRP3 signaling reflects or drives brain neurodegeneration, and whether the eye can serve as a window to CNS neuroinflammation via microglia-derived DAMPs is an unresolved mechanistic question.",
  "domain": "neurodegeneration",
  "status": "resolved",
  "priority_score": 0.62,
  "importance_score": 0.65,
  "tractability_score": 0.6,
  "novelty_score": 0.75,
  "composite_score": 0.64,
  "source": "paper_derived",
  "evidence_summary": "Resolved by hypothesis h-var-08a4d5c07a: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration. Score: 0.907. Supporting PMIDs: 33875891, 30610225, 31748742, 27519954, 33741860.",
  "market_price": 0.5
}