Which specific glymphatic clearance mechanisms are most therapeutically tractable for enhancing protein aggregate removal?

While glymphatic dysfunction was identified as key to neurodegeneration, the debate did not resolve which molecular components (AQP4 polarization, perivascular flow, CSF pulsatility) offer the best therapeutic targets. This mechanistic gap limits drug development approaches. Source: Debate session sess_SDA-2026-04-02-gap-20260402-003058 (Analysis: SDA-2026-04-02-gap-20260402-003058)