How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pathogenesis?

The authors explicitly state that the manner and extent to which autophagy dysfunction in non-neuronal cells contributes to ALS is not fully understood. This gap limits understanding of disease progression and therapeutic targeting strategies.

Gap type: open_question Source paper: Autophagy and ALS: mechanistic insights and therapeutic implications. (2022, Autophagy, PMID:34057020)