Version history

{
  "description": "While HDAC9 is described as an epigenetic regulator affecting cognition and synapses, the specific histone modifications and gene targets are not identified. Defining these targets is essential for understanding HDAC9's therapeutic potential.\n\nGap type: unexplained_observation\nSource paper: Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes. (2026, Mol Psychiatry, PMID:41935184)",
  "domain": "epigenetics",
  "status": "open",
  "priority_score": 0.86,
  "importance_score": 0.85,
  "tractability_score": 0.88,
  "source": "pubmed:41935184",
  "resolution_criteria": "[\"ChIP-seq in primary neurons identifies specific H3K9/14ac and H3K27ac sites regulated by HDAC9 during memory consolidation\", \"HDAC9 knockdown in mouse hippocampus causes measurable deficits in novel object recognition (>30% reduction in discrimination index)\", \"ATAC-seq comparison of HDAC9 KO vs WT neurons reveals 50+ direct target gene promoters with altered chromatin accessibility\", \"Synaptic proteomics identifies 10+ synaptic proteins whose expression is HDAC9-dependent\"]",
  "market_price": 0.5
}