What resolves this contention: Functional anatomy of the ascending spiral: the…

What resolves this contention: Functional anatomy of the ascending spiral: the original primate study inferred a tri-synaptic disinhibitory pathway, while intersectional genetic dissection in mouse finds connectivity present but topology incompatible with simple disinhibition. / Synaptic connectivity in the ascending striatonigrostriatal spiral exists, but the topology cannot support straightforward dorsomedial-to-dorsolateral disinhibition of dopamine signaling as Haber's spiral hypothesis predicted. / An ascending striato-nigro-striatal spiral connects ventral striatum to dorsolateral striatum via SNr-SNc disinhibition, providing a substrate for limbic-to-motor information flow during habit formation.