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What resolves this contention: Whether substituting an expected stimulus with a novel one elicits a prediction-error response in mouse V1; one study reports a sustained firing increase, another reports no significant prediction-error response to substitution. / We find increased neural activity at the time an expected, but omitted, stimulus would have occurred but no significant prediction error responses following an unexpected stimulus substitution. / Substituting a novel stimulus for a familiar one led to increases in firing that persisted for at least 300 ms.
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May 16, 2026
Updated
May 17, 2026

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