What resolves this contention: Histone modifications (especially H3 acetylation…

What resolves this contention: Histone modifications (especially H3 acetylation) at specific gene promoters persist for weeks after drug exposure and causally drive behavioral sensitization and reward / Many reported epigenetic changes are transient and may reflect ongoing transcriptional activity rather than stable epigenetic memory; the causal link often relies on pharmacological HDAC inhibitors with poor specificity