Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

2021 Immunity cited 715×

Shihao Xu; Omkar Chaudhary; Patricia Rodríguez-Morales; Xiaoli Sun; Dan Chen; Roberta Zappasodi; Ziyan Xu; Antônio F. M. Pinto; April E. Williams; Isabell Schulze; Yagmur Farsakoglu; Siva Karthik Varanasi; Jun Siong Low; Wenxi Tang; Haiping Wang; Bryan McDonald; Victoria Tripple; Michael Downes; Ronald M. Evans; Nada A. Abumrad; Taha Merghoub; Jedd D. Wolchok; Maxim N. Shokhirev; Ping‐Chih Ho; Joseph L. Witztum; Brinda Emu; Guoliang Cui; Susan M. Kaech

PMID 34102100
DOI 10.1016/j.immuni.2021.05.003
URL https://doi.org/10.1016/j.immuni.2021.05.003

Abstract

Epub 2021 Jun 7. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors. Xu S(1), Chaudhary O(2), Rodríguez-Morales P(1), Sun X(3), Chen D(1), Zappasodi R(4), Xu Z(5), Pinto AFM(6), Williams A(7), Schulze I(4), Farsakoglu Y(1), Varanasi SK(1), Low JS(8), Tang W(3), Wang H(9), McDonald B(1), Tripple V(1), Downes M(10), Evans RM(10), Abumrad NA(11), Merghoub T(12), Wolchok JD(12), Shokhirev MN(7), Ho PC(9), Witztum JL(3), Emu B(2), Cui G(13), Kaech SM(14).

Abstract

Discussion