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{
  "pmid": "33473216",
  "doi": "10.1101/2020.08.11.245944",
  "abstract": "The anatomy of the mammalian visual system, from the retina to the neocortex, is organized hierarchically1. However, direct observation of cellular-level functional interactions across this hierarchy is lacking due to the challenge of simultaneously recording activity across numerous regions. Here we describe a large, open dataset-part of the Allen Brain Observatory2-that surveys spiking from tens of thousands of units in six cortical and two thalamic regions in the brains of mice responding to a battery of visual stimuli. Using cross-correlation analysis, we reveal that the organization of inter-area functional connectivity during visual stimulation mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas3. We find that four classical hierarchical measures-response latency, receptive-field size, phase-locking to drifting gratings and response decay timescale-are all correlated with the hierarchy. Moreover, recordings obtained during a visual task reveal that the correlation between neural activity and behavioural choice also increases along the hierarchy. Our study provides a foundation for understanding coding and signal propagation across hierarchically organized cortical and thalamic visual areas.",
  "journal": "Nature",
  "year": 2021,
  "authors": "Siegle JH, Jia X, Durand S, Gale S, Bennett C, Graddis N, Heller G, Ramirez TK et al.",
  "url": "https://doi.org/10.1038/s41586-020-03171-x",
  "pmc_id": "PMC7056644",
  "external_ids": {
    "doi": "10.1101/2020.08.11.245944",
    "pmid": "33473216",
    "pmcid": "",
    "source": "openalex+pubmed",
    "openalex": "https://openalex.org/W3124792448",
    "scientist_name": "Christof Koch",
    "scientist_author_orcid_ids": [
      "0000-0001-6482-8067"
    ],
    "scientist_author_openalex_ids": [
      "https://openalex.org/A5084822308"
    ]
  },
  "citation_count": 637
}