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{
  "pmid": "34616071",
  "doi": "10.1038/s41586-021-03970-w",
  "abstract": "An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted<sup>1</sup>. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.",
  "journal": "Nature",
  "year": 2021,
  "authors": "Rodrigo Muñoz-Castañeda, Brian Zingg, Katherine S. Matho, Xiaoyin Chen, Quanxin Wang, Nicholas N. Foster, Anan Li, Arun Narasimhan et al.",
  "url": "https://www.nature.com/articles/s41586-021-03970-w.pdf",
  "external_ids": {
    "doi": "10.1038/s41586-021-03970-w",
    "mag": "3202762561",
    "pmid": "34616071",
    "openalex": "https://openalex.org/W3202762561",
    "scientist_author_slugs": [
      "hongkui-zeng"
    ],
    "scientist_author_orcids": [
      "0000-0002-0326-5878"
    ]
  },
  "citation_count": 275
}