Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease

{'name': "Alzheimer's Research & Therapy", 'volume': '14'} 2022

Weilin Liu, Jianhong Li, Minguang Yang

Abstract

Background The degeneration of the cholinergic circuit from the basal forebrain to the hippocampus contributes to memory loss in patients suffering from Alzheimer’s disease (AD). However, the internal relationships between the acetylcholine (Ach) cycle and memory decline during the early stages of A

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