Genetic Dissection of Neural Circuits: A Decade of Progress

Neuron 2018 496 cites
2018:222019:322020:432021:542022:622023:672024:712025:732026:72
2018 2026
496

Luo, Liqun and Callaway, Edward M. and Svoboda, Karel

Abstract

Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have been carried out in a multitude of invertebrate and vertebrate organisms, linking neurons and circuits to behavioral functions. New methods allow systematic classification of cell types and provide genetic access to diverse neuronal types for studies of connectivity and neural coding during behavior. Here we evaluate key advances over the past decade and discuss future directions.

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