10.1016/j.neuron.2021.01.003

Neuron 2021 159 cites
2021:102022:192023:272024:322025:352026:36
2021 2026
159

Dudok, Barna and Klein, Peter M. and Hwaun, Ernie and Lee, Brian R. and Yao, Zizhen and Fong, Olivia and Bowler, John C. and Terada, Satoshi and Sparks, Fraser T. and Szabo, Gergely G. and Farrell, Jordan S. and Berg, Jim and Daigle, Tanya L. and Tasic, Bosiljka and Dimidschstein, Jordane and Fishell, Gord and Losonczy, Attila and Zeng, Hongkui and Soltesz, Ivan

Abstract

Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior.

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