Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review.

CNS Spectr 2022

Palagini L, Geoffroy PA, Miniati M

Abstract

  1. CNS Spectr. 2022 Jun;27(3):298-308. doi: 10.1017/S1092852921000018. Epub 2021 Jan 11.

Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review.

Palagini L(1), Geoffroy PA(2)(3), Miniati M(1), Perugi G(1), Biggio G(4), Marazziti D(1), Riemann D(5).

Author information: (1)Department of Experimental and Clinic Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy. (2)Département de psychiatrie et d’addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hopital Bichat - Claude Bernard, F-75018 Paris, France. (3)Université de Paris, Paris, NeuroDiderot, Inserm U1141, F-75019 Paris, France. (4)Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy. (5)Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase electronic databases for literature related to mood disorders, sleep disturbances, and neurodegenerative/neuroprogressive processes in relation to (1) neuroinflammation, (2) activation of the stress system, (3) oxidative stress, (4) accumulation of neurotoxic proteins, and (5) neuroprotection deficit. Seventy articles were collectively selected and analyzed. Experimental and clinical studies revealed that insomnia, conditions of sleep loss, and altered circadian sleep may favor neurodegeneration and neuroprogression in mood disorders. These sleep disturbances may induce a state of chronic inflammation by enhancing neuroinflammation, both directly and indirectly, via microglia

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