Uncommon inflammatory/immune-related myelopathies.

J Neuroimmunol 2021 2 cites
2021:02022:02023:02024:02025:02026:2
2021 2026
2

Valencia-Sanchez C, Flanagan EP

Abstract

  1. J Neuroimmunol. 2021 Dec 15;361:577750. doi: 10.1016/j.jneuroim.2021.577750. Epub 2021 Oct 13.

Uncommon inflammatory/immune-related myelopathies.

Valencia-Sanchez C(1), Flanagan EP(2).

Author information: (1)Neurology Department, Mayo Clinic, Rochester, MN, USA. (2)Neurology Department, Mayo Clinic, Rochester, MN, USA. Electronic address: flanagan.eoin@mayo.edu.

The differential diagnosis for immune-mediated myelopathies is broad. Although clinical manifestations overlap, certain presentations are suggestive of a particular myelopathy etiology. Spine MRI lesion characteristics including the length and location, and the pattern of gadolinium enhancement, help narrow the differential diagnosis and exclude an extrinsic compressive cause. The discovery of specific antibodies that serve as biomarkers of myelitis such as aquaporin-4-IgG and myelin-oligodendrocyte -glycoprotein-IgG (MOG-IgG), has improved our understanding of myelitis pathophysiology and facilitated diagnosis. In this review we will focus on the pathophysiology, clinical presentation, imaging findings and treatment and outcomes of uncommon immune-mediated myelopathies.

Copyright © 2021 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.jneuroim.2021.577750 PMID: 34715593 [Indexed for MEDLINE]

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