Abstract
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Nature. 2022 Apr;604(7907):714-722. doi: 10.1038/s41586-022-04640-1. Epub 2022 Apr 20.
Somatic genomic changes in single Alzheimer’s disease neurons.
Miller MB(#)(1)(2)(3)(4), Huang AY(#)(2)(3)(4), Kim J(2)(3)(4)(5), Zhou Z(2)(4), Kirkham SL(2)(4), Maury EA(2)(3)(4)(6), Ziegenfuss JS(7), Reed HC(2)(4)(8), Neil JE(2)(4)(9), Rento L(2)(4)(9), Ryu SC(2)(4), Ma CC(2)(4), Luquette LJ(10), Ames HM(11), Oakley DH(12), Frosch MP(12)(13), Hyman BT(13), Lodato MA(14)(15)(16), Lee EA(17)(18)(19), Walsh CA(20)(21)(22)(23)(24).
Author information: (1)Division of Neuropathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. (2)Division of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children’s Hospital, Boston, MA, USA. (3)Broad Institute of MIT and Harvard, Cambridge, MA, USA. (4)Department of Pediatrics, Harvard Medical School, Boston, MA, USA. (5)Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea. (6)Bioinformatics and Integrative Genomics Program, Harvard-MIT MD-PhD Program, Harvard Medical School, Boston, MA, USA. (7)Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. (8)Allegheny College, Meadville, PA, USA. (9)Howard Hughes Medical Institute, Boston, MA, USA. (10)Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. (11)Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA. (12)Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA. (13)Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA. (14)Division of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children’s Hospital, Boston, MA, USA. michael.lodato@umassmed.edu. (15)Department of Pediatrics, Harvard Medical School, Boston, MA, USA. michael.lodato@umassmed.edu. (16)Department