Cellular anatomy of the mouse primary motor cortex
Nature·2021275 cites
20212026
275
Mu{\~n}oz-Casta{\~n}eda, Rodrigo and Zingg, Brian and Matho, Katherine S. and Chen, Xiaoyin and Wang, Quanxin and Foster, Nicholas N. and Li, Anan and Narasimhan, Arun and Hirokawa, Karla E. and Huo, Bingxing and Bannerjee, Samik and Korobkova, Laura and Park, Chris Sin and Park, Young-Gyun and Bienkowski, Michael S. and Chon, Uree and Wheeler, Diek W. and Li, Xiangning and Wang, Yun and Naeemi, Maitham and Xie, Peng and Liu, Lijuan and Kelly, Kathleen and An, Xu and Attili, Sarojini M. and Bowman, Ian and Bludova, Anastasiia and Cetin, Ali and Ding, Liya and Drewes, Rhonda and D'Orazi, Florence and Elowsky, Corey and Fischer, Stephan and Galbavy, William and Gao, Lei and Gillis, Jesse and Groblewski, Peter A. and Gou, Lin and Hahn, Joel D. and Hatfield, Joshua T. and Hintiryan, Houri and Huang, Junxiang Jason and Kondo, Hideki and Kuang, Xiuli and Lesnar, Philip and Li, Xu and Li, Yaoyao and Lin, Mengkuan and Lo, Darrick and Mizrachi, Judith and Mok, Stephanie and Nicovich, Philip R. and Palaniswamy, Ramesh and Palmer, Jason and Qi, Xiaoli and Shen, Elise and Sun, Yu-Chi and Tao, Huizhong W. and Wakemen, Wayne and Wang, Yimin and Yao, Shenqin and Yuan, Jing and Zhan, Huiqing and Zhu, Muye and Ng, Lydia and Zhang, Li I. and Lim, Byung Kook and Hawrylycz, Michael and Gong, Hui and Gee, James C. and Kim, Yongsoo and Chung, Kwanghun and Yang, X. William and Peng, Hanchuan and Luo, Qingming and Mitra, Partha P. and Zador, Anthony M. and Zeng, Hongkui and Ascoli, Giorgio A. and Josh Huang, Z. and Osten, Pavel and Harris, Julie A. and Dong, Hong-Wei
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted1. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.
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