Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types

(Cell Reports 40, 111176; August 9, 2022) After publication, the text was updated to better reflect certain conclusions resulting from the analysis presented in Figure 5. A new clause was added to the final sentence of the relevant paragraph stating that “other aspects of morphology and passive membrane properties” could potentially also contribute to the observed trends in EPSP integration along with the Ih conductance differences discussed. Two sentences earlier in the paragraph regarding the normalized PSP size metric were also edited to clarify how this metric specifically eliminates effects of input resistance on the reported observations, yet without completely excluding other effects. The authors apologize for any confusion. Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell typesNandi et al.Cell ReportsAugust 09, 2022In BriefIntegrating and reconciling multimodal cellular datasets has been challenging. Nandi et al. generate models that are robust representations of cellular experiments and cortical cell types defined by electrophysiology, morphology, or transcriptomics. These models causally link between seemingly disparate modalities offering mechanistic hypotheses about cellular phenotypes. Full-Text PDF Open Access