Browsing all papers, sorted by Most cited. Showing 3 of 39,449.
STING orchestrates the neuronal inflammatory stress response in multiple sclero…
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress response, we discovered that neurons in MS and its mouse model induce the stimulator of interferon genes (STING). However, activation of neuronal STING requires its detachment fr…
["Animals""Multiple Sclerosis""Membrane Proteins""Neurons"Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here, we find that one GSDM family member, GSDME, is expressed by both mouse and human neurons. GSDME plays a role…
["Amyotrophic Lateral Sclerosis""Frontotemporal Dementia""Gasdermins""Axons"Neurodegeneration and demyelination in multiple sclerosis.
Progressive multiple sclerosis (PMS) is an immune-initiated neurodegenerative condition that lacks effective therapies. Although peripheral immune infiltration is a hallmark of relapsing-remitting MS (RRMS), PMS is associated with chronic, tissue-restricted inflammation and disease-associated reactive glial states. The effector functions of disease-associate…
["Humans""Animals""Multiple Sclerosis""Demyelinating Diseases"