25 results for “Aging and Healthspan”. Showing 25 of 39,449.
Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice.
candidates for delaying aging and improving healthspan in aged male mice.
Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.
age, while modestly improving composite healthspan measures. Gene expression analysis
An epigenetic biomarker of aging for lifespan and healthspan.
age that capture differences in lifespan and healthspan may identify
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Aging, The Scripps Research Institute, Jupiter, FL, USA. The healthspan
Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice.
healthspan of naturally aged mice. HK treatment inhibited age-induced
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
healthspan in aged mice. Our results reveal that apoptosis and senescence
The metabolic footprint of aging in mice.
such, these metabolites serve as biomarkers for aging and healthspan.
The mTOR signaling pathway in cardiac aging.
aging, lifespan, and healthspan through the regulation of protein synthesis
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging.
aging. Understanding how TRF/TRE re-engages mitochondrial and vascular repair programs offers a translational framework for developing accessible, non-pharmacological strategies to extend healthspan
Hallmarks of cardiovascular ageing.
healthspan and lifespan. Therefore, cardiovascular ageing might precede or even
The Role of Nutraceuticals and Functional Foods in Mitigating Cellular Senescence and Its Related Aspects: A Key Strategy for Delaying or Preventing Aging and Neurodegenerative Disorders.
healthspan by targeting mechanisms associated with aging. Cellular senescence is recognized
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan
Causality-enriched epigenetic age uncouples damage and adaptation.
healthspan, facilitating the development of aging biomarkers, assessing interventions, and studying
Causality-enriched epigenetic age uncouples damage and adaptation.
healthspan, facilitating the development of aging biomarkers, assessing interventions, and studying
Pleiotropic Effects of mTOR and Autophagy During Development and Aging.
aging cell or organism, causing enhanced healthspan and even longevity
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging.
induction as a strategy to decrease age-associated inflammation and increase healthspan.
Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice.
aging cannot currently be prevented, its impact on life- and healthspan
Cellular senescence, DNA damage, and neuroinflammation in the aging brain.
age-related conditions, including memory impairment and progressive loss of brain volume. As brain health is essential to promoting healthspan
Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets.
healthspan. Sirtuin activity and NAD+ levels decrease with age in many
Dietary restriction in aging and longevity.
healthspan and treat, prevent or delay age-related diseases including
Mechanisms of spermidine-induced autophagy and geroprotection.
Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several recently discovered compounds that extend the healthspan
Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in
aged brain. Importantly, neuronal induction of BNIP3-mediated mitophagy increases organismal longevity and healthspan
Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities.
aging has emerged as a promising strategy to extend healthspan
The Use of Metformin to Increase the Human Healthspan.
age-associated declines. The current review summarizes advances in clinical research on the potential role of metformin in the field of lifespan and healthspan
Apheresis for senescence: Targeting the senescence-associated secretory phenotype to delay aging and age-related diseases.
healthspan. This review explores the mechanistic basis of SASP in aging