25 results for “Cellular Clearance Mechanisms”. Showing 25 of 39,449.
Bridging autophagy and endolysosomal dysfunction: Role of bridging integrator 1 in Alzheimer's disease.
cellular clearance mechanisms to the development of toxic amyloid-beta
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
cellular clearance mechanisms. Whether the levels of FKBP (FK506 binding
Pharmacological activation of mitophagy antagonizes motor neuron degeneration in a cross-species platform of amyotrophic lateral sclerosis.
cellular mechanism for the selective clearance of damaged mitochondria. While
Autophagy and Alzheimer's Disease: Mechanisms and Impact Beyond the Brain.
mechanism in cellular homeostasis, mediating the clearance of misfolded proteins
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.
clearance at the BBB. The cellular and molecular mechanisms, however
How autophagy can restore proteostasis defects in multiple diseases?
clearance of unwanted materials and regulations of several cellular mechanisms
Simvastatin exerts neuroprotective effects post-stroke by ameliorating endoplasmic reticulum stress and regulating autophagy/apoptosis balance through pAMPK/LC3B/ LAMP2 axis.
mechanism by which statin leads to neuronal survival by the mitophagy mediated cellular clearance
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.
mechanism. Given the demonstrated roles of TRPML1 and TFEB in cellular clearance
Mitophagy and Neuroprotection.
mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular
Parkinson's Disease-Related Genes and Lipid Alteration.
clearance, and neuroinflammation, but a common molecular mechanism connecting the different cellular
Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury.
mechanisms were explored at the animal and cellular levels. Finally, we validated the clearance
Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease.
clearance of damaged mitochondria and other cellular debris by autophagy and mitophagy mechanisms
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
clearance of Aβ. Our findings reveal for the first time a cellular and molecular mechanism
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular
Cinnamaldehyde and its combination with deferoxamine ameliorate inflammation, ferroptosis and hematoma expansion after intracerebral hemorrhage in mice.
mechanisms driving brain injury are complex and include inflammation, oxidative stress, glutamate excitotoxicity, membrane damage, lipid peroxidation, ferroptosis and other cellular death modes. Hematoma clearance
LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein.
Numerous proteins participate and actively contribute to the various cellular
Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century.
mechanisms of PM-induced toxicological effects are related to their size, chemical composition, lung clearance and retention, cellular
Neuronal Vulnerability of the Entorhinal Cortex to Tau Pathology in Alzheimer's Disease.
clearance of pathological tau aggregates and the inhibition of tau aggregation processes. By understanding the molecular and cellular mechanisms
Visualization of autophagic structures near solid polyQ aggregates reveals how they undermine autophagy.
cellular proteostasis and macroautophagy/autophagy has been proposed to be an important tool in the clearance of polyQ aggregates. The mechanism
Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism.
cellular integrity. Dysregulation of glutamate signalling also triggers astrocytic stress responses, leading to reduced glutamate clearance, thus worsening neuronal damage through excitotoxic mechanisms
Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.
cellular antioxidant responses. NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2), a transcriptional factor that controls the expression of multiple detoxifying enzymes through antioxidant response elements (AREs), is a proposed target
Sleep loss impairs blood-brain barrier function: Cellular and molecular mechanisms.
clearance of potentially neurotoxic metabolites and byproducts of neural physiology, which may eventually contribute to neurodegenerative diseases. This chapter aims to describe the cellular and molecular mechanisms
Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.
mechanism by which autophagy mediates the degradation of APP-CTF and the clearance of amyloid β. Through affinity purification followed by mass spectrum analysis, we identified adaptor protein
Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders.
clearance and tissue repair, chronic and dysregulated inflammation contributes significantly to the progression of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Multiple Sclerosis. This review explores
Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy-Lysosome Pathway.
mechanisms are not fully understood. Here, it is found that the injection of chondroitinase ABC (ChABC), mimicking ECM remodeling, into the medial prefrontal cortex (mPFC) reversed short-term memory loss