25 results for “Cellular Trafficking”. Showing 25 of 39,449.
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.
cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
cellular function of the C9ORF72 protein remains unknown. Here, we demonstrate that C9ORF72 regulates endosomal trafficking
The role of Alzheimer's disease risk genes in endolysosomal pathways.
cellular trafficking differently (see Fig. 1). Challenges ahead involve defining
SORL1 is a receptor for tau that promotes tau seeding.
trafficking. The objective of these studies was to test the hypothesis that SORL1 binds tau, modulates its cellular
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease.
cellular trafficking of SorLA protein could be due to subtle
Conjugated Oligoelectrolytes as Optical Probes.
cellular trafficking. Conjugated oligoelectrolytes (COEs), an emerging class of optical
Cell type-specific functions of Alzheimer's disease endocytic risk genes.
cellular trafficking and membrane dynamics. The endocytic pathway has been
Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination.
cellular trafficking, and key molecular pathways of innate immunity, with
Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.
cellular trafficking of amyloid precursor protein and plays an essential
Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.
cellular trafficking and transport function. The resulting alteration in glutamate
Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics.
cellular trafficking, biodistribution, safety, and pharmacokinetics. We establish how transcytosis
γ-secretase facilitates retromer-mediated retrograde transport.
trafficking of retromer-dependent retrograde cellular cargoes, divalent metal transporter
Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology.
trafficking, and cellular organization across multiple tissues. Although extensively studied
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
cellular material for trafficking to the lysosome. Human beclin-1 and its yeast
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging.
cellular AMPA receptor trafficking events that control synaptic responsiveness and plasticity
The
cellular localization, and trafficking in cell-based assays. Under physiological
Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease.
trafficking in in vitro cellular assays, and 17 variants with
The P2X7 Receptor.
P2X7 receptor, and its cellular localisation and trafficking within cells.
Flotillin membrane domains in cancer.
Trafficking (UFIT) pathway include molecules involved in signaling, adhesion, and extracellular matrix remodeling, thus favoring the acquisition of an invasive cellular
News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.
trafficking of LDLR and consequently the clearance of circulating LDL cholesterol have recently been reported. Mutations in some of these proteins cause hypercholesterolemia in human. In addition, LRP1 controls cellular
Lysosomal trafficking markers covering PSAP, PGRN, SORT1 and LRP1 in body liquids and cerebral tissue as auxiliary indicative tool of traumatic brain injury.
cellular evidence suggests lysosomal trafficking disruption as central element of fatal
Differential effects of
trafficking are an early cellular symptom in AD and a novel
Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.
cellular processes associated with the trafficking of membrane-delivered cargo
RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease.
trafficking, and LRRK2 activity, its cellular function remains unclear. In the current
Functional analysis of optineurin and some of its disease-associated mutants.
cellular functions such as protein trafficking by vesicles, autophagy, and signal