25 results for “Clinical Research Methodology”. Showing 25 of 39,449.
Medical librarians' knowledge and practices in locating clinical trials for systematic reviews.
methodology. A survey was developed to explore these aspects of how a medical librarian locates clinical trials when facilitating systematic reviews for researchers
Neurodegeneration: 2024 update.
clinical neuropathologists. A concerted effort was made to balance the selected studies across neurodegenerative disease categories, approaches, and methodologies to capture the breadth of the research
Magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment.
clinical settings. Future research is needed to warrant the inclusion for more advanced MRI methodology
Epigenetics in chronic rhinosinusitis.
clinical variability. Their modulation offers novel opportunities for biomarker discovery, disease stratification, and personalized therapy. Future research should focus on standardizing epigenetic profiling methodologies
Cultural Adaptation of a Digital Mobile App for Bipolar Disorder (PolarUs): Protocol for a Qualitative Co-Design Study.
methodologies, and inform preparation for a future clinical trial. This study will produce the first culturally adapted, BD-specific DMHI developed through co-design using a community-based participatory research
Impact of Peripheral Inflammation on Blood-Brain Barrier Dysfunction and Its Role in Neurodegenerative Diseases.
research should leverage cutting-edge methodologies such as single-cell transcriptomics and organ-on-chip models to translate preclinical findings into effective clinical
CryoSCAPE: Scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays
clinical isolation and preservation limit their application in underserved communities with limited access to research facilities. We present CryoSCAPE (Cryopreservation for Scalable Cellular And Proteomic Exploration), a scalable method
CryoSCAPE: Scalable Immune Profiling Using Cryopreserved Whole Blood for Multi-omic Single Cell and Functional Assays
clinical isolation and preservation limit their application in underserved communities with limited access to research facilities. We present CryoSCAPE (Cryopreservation for Scalable Cellular And Proteomic Exploration), a scalable method
Advancing brain tumor therapy: unveiling the potential of PROTACs for targeted protein degradation.
methodology, including design, sample size, and data analysis techniques. A narrative synthesis summarized key outcomes and trends in PROTAC-based brain tumor therapy. Recent research shows PROTACs selectively degrade brain
Multiligament knee injury (MLKI): an expert consensus statement on nomenclature, diagnosis, treatment and rehabilitation.
clinical care and research. This study aimed to develop consensus on the nomenclature, diagnosis, treatment and rehabilitation strategies for patients with MLKI, while identifying important research priorities for further study
Consensus guideline for the diagnosis and treatment of aromatic l-amino acid decarboxylase (AADC) deficiency.
methodology. In the face of limited definitive evidence, we constructed practical recommendations on clinical diagnosis, laboratory diagnosis, imaging and electroencephalograpy, medical treatments and non-medical treatments. Furthermore, we identified topics
Ideas for how informaticians can get involved with COVID-19 research.
clinical problems. The goal of this editorial is to highlight some examples of COVID-19 research areas that could benefit from informatics expertise. Each research idea summarizes the COVID
Electrocardiographic imaging in the atria.
methodologies, regularization methods, and post-processing techniques used in the atria, as well as the context in which they are used. The current advantages and limitations of ECGI
Pain in monogenic Parkinson's disease: a comprehensive review.
clinical trials and the development of personalized treatments for pain in monogenic PD. In conclusion, this review underscores the need for further research to unravel the intricate relationship between pain
Oxymatrine impedes Alzheimer's progression via the attenuation of hypercholesterolemia and fibrosis.
research explores how oxymatrine regulates mediators involved in oxysterol production and fibrotic alterations in AD. Preliminary results suggest that oxymatrine has the potential to significantly delay the development and progression
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges.
methodological limitations such as variability in cargo content, and proposes solutions to enhance standardization and safety. Collectively, these insights highlight the translational potential of exosomes and offer a novel perspective
Parkinson's Disease Subtypes: Critical Appraisal and Recommendations.
research or clinical practice. To critically evaluate PD subtyping systems. We conducted a systematic review of PD subtypes, assessing the characteristics of the studies reporting a subtyping system
Financial Conflicts of Interest Among Emergency Medicine Contributors on Free Open Access Medical Education (FOAMed).
methodologic process of critically appraising a peer-reviewed publication with a summary recommendation regarding whether the conclusions of the publication were clinically relevant to emergency medicine practice. We excluded
Effective deep convolutional neural network with attention mechanism for Alzheimer disease classification.
methodological constraints and insufficient clinical scrutiny. The current systems struggle to reliably predict the disorder in its initial stages. To reduce the need for frequent clinical visit and lower diagnostic
Atopic dermatitis in the elderly: a review of clinical and pathophysiological hallmarks.
research gap exists regarding specific ageing-related changes in AD disease development. More knowledge about AD in the elderly is needed to establish firm diagnostic and treatment methodologies. What
Eight diseases for gene therapy accelerator
clinical outcomes, particularly with respect to adverse events such as liver toxicity, immune responses, and tissue tropism. Microphysiological systems (MPS), including organoids and organs-on-chips, offer a promising
Eight diseases for gene therapy accelerator.
clinical outcomes, particularly with respect to adverse events such as liver toxicity, immune responses, and tissue tropism. Microphysiological systems (MPS), including organoids and organs-on-chips, offer a promising
Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2).
methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations
New horizons at the interface of artificial intelligence and translational cancer research.
research as a computational strategy for analyzing multiomics datasets. Advances in single-cell and spatial profiling technologies have contributed significantly to our understanding of tumor biology, and AI methodologies
Homocysteine and diabetic retinopathy.
clinical associations remain contentious due to heterogeneity in study populations, confounding factors like renal function, and methodological variations. We critically evaluate this translational evidence and explore the therapeutic potential