25 results for “Clinical Translation”. Showing 25 of 39,449.
Challenges and recommendations for the translation of biomarkers of aging.
translational geroscience and improving healthspan. However, clinical translation remains limited
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
clinically-translatable, practical strategies for increasing α-Klotho are not at hand
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School
Chemokine Networks in Blood-Brain Barrier Regulation: Bidirectional Mechanisms, Clinical Translation, and Precision Therapeutic Prospects.
clinical translation challenges caused by the redundancy and spatiotemporal heterogeneity
Clinical translation of stem cell transplantation in Parkinson's disease.
clinical translation. Important challenges include the demonstration of potency (growth
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosomal function via Sirt3 signaling to ameliorate neurodegenerative pathology.
clinical translation of aptamer-modified ENVs as precision nanomedicines for neurodegenerative
Extracellular vesicles: A new therapeutic drug for nerve injury repair.
clinical translational potential of extracellular vesicles from different sources, including
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next-Generation Therapies.
clinical translation is hindered by rapid enzymatic degradation, short half
Mitochondrial Dysfunction and Parkinson's Disease-Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy.
clinical translation. Nonetheless, PBM represents a potential novel therapy for PD. In this
Exosomes based strategies for brain drug delivery.
clinical translation. Exosomes are nanoscale membrane-bound vesicles primarily involved
An expert narrative review on the brain-kidney axis in diabetic kidney disease: Mechanisms and therapeutic insights.
clinical translational potential remains incompletely defined. OBJECTIVE: To comprehensively evaluate
A human neuron alzheimer's disease model reveals barriers to senolytic translatability.
translate into clinical trials, with experimental drugs rarely validated in human
Validation of biomarkers of aging.
translation to the clinic. Here, we review current efforts to evaluate
Translating diagnostics and drug delivery technologies to low-resource settings.
translated to the clinic. Here, we identify factors that contribute
Nose-to-brain delivery of stem cells in stroke: the role of extracellular vesicles.
clinic translational hurdles, namely the identification of well-characterized, clinical
Gene therapy for CNS disorders: modalities, delivery and translational challenges.
translate gene therapy to the clinic have failed to make
Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy.
clinical trial further supports the translational feasibility of ICO immune
Melatonin: A potential nighttime guardian against Alzheimer's.
clinical translation. These include conducting additional randomized clinical trials in patients
Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease.
translational therapeutic pipeline, including biomarker development and clinical trial strategies
Adaptive multi-degree-of-freedom in situ bioprinting robot for hair-follicle-inclusive skin repair: A preliminary study conducted in mice.
clinical, which are the bottlenecks hindering the translation of skin
Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans
clinical translation based on new understanding of how specific cell
Selenium and brain aging: A comprehensive review with a focus on hippocampal neurogenesis.
clinical translation remains limited by heterogeneous and short-term studies
Emerging Concepts in Vascular Dementia: A Review.
translates into clinically significant cognitive impairment. For example, a cerebral
Pathomechanisms, genetic insights, and therapeutics in diabetes-associated dementia.
clinical translation of these therapies remains challenging due to the complexity
cGAS-STING and neurodegenerative diseases: A molecular crosstalk and therapeutic perspective.
clinical translation, necessitating optimized drug delivery and immune modulation. With