25 results for “Epigenetic Therapeutics”. Showing 25 of 39,449.
Disrupting the epigenetic alliance: structural insights and therapeutic strategies targeting DNMT1-UHRF1.
epigenetic therapeutics that directly disrupt the DNMT1-UHRF1 maintenance machinery
Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics.
Epigenetic regulator bromodomain-containing protein 4 (BRD4) is critical in controlling gene expression of IBD-associated inflammatory cytokine networks. BRD4 as a promising therapeutic
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment.
Therapeutic epigenetic modulation is currently being evaluated in the clinic
Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate.
epigenetic therapeutic agent, valproate, shown previously to protect dopaminergic SNpc
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neuropsychiatric co-morbidities.
epigenetic modulation. Building on these findings, we evaluate therapeutic strategies
Epigenetic reprogramming as a therapeutic strategy for neurodegenerative diseases: A complex and novel approach.
Epigenetic reprogramming has emerged as a promising therapeutic strategy for neurodegenerative
Reversing Epigenetic Dysregulation in Neurodegenerative Diseases: Mechanistic and Therapeutic Considerations.
epigenetic modulators offer an integrated strategy to address the multifactorial nature of NDDs, altering their therapeutic
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets.
epigenetic and post-translational modulation, resulting in alterations in autophagy levels, which subsequently induces disease or affects the therapeutic
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.
epigenetic adaptability, contributing to therapeutic resistance and tumor recurrence. The mechanisms
The epigenetics of aging and neurodegeneration.
epigenetics-based therapeutic strategies for these diseases, which either aim to restore
Molecular mechanism underlying stress response and adaptation.
therapeutic research. Epigenetic influences and genomic modifications highlight the long
Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook
Alzheimer's Disease-Related Epigenetic Changes: Novel Therapeutic Targets.
epigenetic modifications and factors on memory and plasticity throughout life, emphasizing their potential as target for therapeutic
Shared and distinct effects of mood stabilizers on epigenetic machinery gene expression: an exploratory study in HeLa cells.
therapeutic effects through epigenetic modulations. In this exploratory study, we investigated
Epigenetics in chronic rhinosinusitis.
epigenetics in CRS pathogenesis, their role in endotype differentiation, and potential as diagnostic and therapeutic
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options.
epigenetic mechanisms that govern these changes and developing therapeutic approaches
Epigenetic regulation in Huntington's disease.
epigenetic alterations. Finally, we discuss the therapeutic potential of epigenetic
Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer's pathophysiology: unveiling therapeutic potential.
epigenetic agents and safe therapeutic approaches for managing Alzheimer's disease
Mitochondrial quality control: Epigenetic signatures and therapeutic strategies.
epigenetic mechanisms such as DNA methylation and histone modulation participating in such neurological disorders have also been discussed. Apart from it, therapeutic
Epigenetic mechanisms linking environmental exposure to Parkinson's disease: A comprehensive review.
epigenetic landscape in PD and explores their downstream effects on key pathological processes. We also discuss emerging therapeutic
SMARCA4: Current status and future perspectives in non-small-cell lung cancer.
therapeutic strategies for this subtype. This review systematically describes the biological functions of SMARCA4 and its role in NSCLC development, metastasis, functional epigenetics
The class-IIa HDAC inhibitor TMP269 promotes BMP-Smad signalling and is neuroprotective in in vitro and in vivo 6-hydroxydopamine models of Parkinson's disease.
therapeutic goal. Pan-inhibitors of histone deacetylase (HDAC) enzymes, key epigenetic
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
therapeutic value. Here, we show that epigenetic modulation through bromodomain
Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysis.
therapeutic potential in vitro, including potent anti-osteoclastic activity, ROS scavenging capacity, and epigenetic
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders.
epigenetic factors and, especially, their role as mediators between the genome and the environment make them exciting candidates as therapeutic