25 results for “Metabolic brain disease”. Showing 25 of 39,449.
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases.
Brain Lipid Metabolism and Neurodegenerative Diseases. Hussain Y(1)(2), Dar MI(1)(2), Pan X(1)(2). Author
microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain.
Brain lipid metabolism, in particular Apolipoprotein E (ApoE) lipidation, is critical to Aβ metabolism and Alzheimer's disease
Bioenergetic regulation of microglia.
disease. Brain energy metabolism and substrate availability vary under normal
Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism.
brain-specific cholesterol-metabolizing enzyme, CYP46A1, which converts cholesterol into 24S-hydroxycholesterol (24S-HC). However, drugs effective against scrapie prions often fail in human prion diseases
Molecular and metabolic heterogeneity of astrocytes and microglia.
diseased brain, ranging from metabolism to immunity. The crosstalk between
Trans-activator of transcription-pre-B-cell leukemia transcription factor 1 alleviates Alzheimer's disease by reducing neuronal insulin resistance and restoring energy homeostasis.
disease-induced pathology. The case-control analysis identified pre-B-cell leukemia transcription factor 1 as a crucial regulator of brain metabolic
Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer's pathology and dementia in the CFAS population-derived neuropathology cohort.
metabolism is implicated in brain ageing and Alzheimer's disease
Microglial Metabolic Reprogramming: Emerging Insights and Therapeutic Strategies in Neurodegenerative Diseases.
Diseases This graphical abstract illustrates the metabolic shift in microglial cells in response to pathological stimuli and highlights potential therapeutic strategies targeting microglial metabolism for improved brain
Cholesterol metabolism in aging simultaneously altered in liver and nervous system.
diseases are also related to brain aging, inducing changes in cholesterol metabolism
Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism.
metabolic dysfunction are early alterations in Alzheimer's disease brain
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.
brain glucose metabolism and accumulation of abnormal protein deposits called plaques and tangles are neuropathological hallmarks of Alzheimer's disease
Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment.
brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically
Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases.
disease-specific mechanisms rather than the shared metabolic vulnerability of the brain
Amyloid beta increases ABCA1 and HMGCR protein expression, and cholesterol synthesis and accumulation in mice neurons and astrocytes.
metabolism in the brain is one of the main pathophysiological mechanisms involved in Alzheimer's disease
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway.
metabolism is known to affect brain activity in neurodegenerative diseases
Cholesterol Metabolism in Neurodegenerative Diseases.
metabolism in the brain has been linked to impaired brain function and the onset of neurodegenerative diseases
Clinical and biomarker changes in dominantly inherited Alzheimer's disease.
disease, brain amyloid deposition, and brain metabolism as well as progressive
10.1016/j.yfrne.2013.08.001
brain bioenergetics and shift towards a metabolically compromised phenotype. Compensatory bioenergetic adaptations, or lack thereof, to estrogen loss could determine risk of late-onset Alzheimer's disease
Restoration of glucose metabolic homeostasis for treating CNS diseases: mechanistic insights and potential clinical prospect.
Brain glucose metabolism orchestrates central nervous system (CNS) homeostasis via cell-type-specific metabolic networks and metabolite-mediated signaling. Recent studies have shown that dysregulated glucose metabolism can disrupt energy
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.
metabolism syndrome, atherosclerosis, and brain diseases. In this book chapter
Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to high fat diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine (NAC).
strategy for conserving brain health against metabolic diseases-induced neurodegeneration.
mTOR-Mediated Immunometabolic Reprogramming Nanomodulators Enable Sensitive Switching of Energy Deprivation-Induced Microglial Polarization for Alzheimer's Disease Management.
Metabolic reprogramming that senses brain homeostasis imbalances is necessary to drive detrimental microglial polarization, and specific targeting of this process contributes to the flexible control of pathological inflammatory responses
Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms.
Multiple organs and tissues coordinate to respond to dietary and
Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review.
metabolism of cholesterol in the brain can be associated with beta-amyloid plaques formation, which is seen in Alzheimer's disease
"Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders".
metabolic shifts in response to disease-targeted pathologies in Alzheimer's, Parkinson's, Multiple Sclerosis, ischemic stroke, and traumatic brain