25 results for “Nucleic Acids Research”. Showing 25 of 39,449.
A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease.
Research (CSIR), Mall Road, New Delhi, -110007, India. (2)Department of Chemistry, Nucleic Acids
Author response: A simple method for generating high-resolution maps of genome-wide protein binding
Nucleic Acids Research 36:e125. https://doi.org/10.1093/nar/gkn535 Google Scholar
Author response: A simple method for generating high-resolution maps of genome-wide protein binding
Nucleic Acids Research 36:e125. https://doi.org/10.1093/nar/gkn535 Google Scholar
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges.
nucleic acid-based therapies (NA-BTs) in biological research. However
Lipid Messengers: Mechanisms and Clinical Applications of Exosomal Lipids in Neurodegenerative Diseases.
research has predominantly focused on exosomal proteins and nucleic acids
The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential Antioxidant Effect.
nucleic acids (LNAs) are at the forefront of proof-in-concept therapeutics. Future research
The next generation of CRISPR-Cas technologies and applications.
research ranging from fundamental science to translational medicine. Initial successes have inspired efforts to discover new systems for targeting and manipulating nucleic acids
Programmable peroxidase-assisted signal amplification enables flexible detection of nucleic acid targets in cellular and histopathological specimens
nucleic acid detection to robust signal amplification capable of diverse readouts, pSABER will have broad utility in research
Efficient and highly amplified imaging of nucleic acid targets in cellular and histopathological samples with pSABER
nucleic acid detection to robust signal amplification capable of diverse readouts, pSABER will have broad utility in research
Emerging Role of Extracellular Vesicles in Intercellular Communication in the Brain: Implications for Neurodegenerative Diseases and Therapeutics.
nucleic acids, and lipids. The identification of EVs as pivotal agents in intercellular communication has sparked compelling research
An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment.
research purposes, given the amount of ongoing clinical trials based on this strategy to treat GBM, and neoantigen and nucleic acid
Nucleic acid liquid biopsies in Alzheimer's disease: current state, challenges, and opportunities.
nucleic acid species associated with AD from liquid tissues. Differences in cell-free RNAs and DNAs have been described as potential biomarkers for AD and hold the potential to affect
Decoding Cancer through Silencing the Mitochondrial Gatekeeper VDAC1.
nucleic acids, phospholipids, fatty acids, cholesterol, and porphyrins. Given its multifunctional nature and overexpression in many cancers, VDAC1 presents an attractive target for therapeutic intervention. Our research
The Nasal-Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases.
research development of neurodegenerative diseases, acute neurological diseases, brain tumor, and psychiatric disorders when using NBDD drugs encompassing small-molecule drugs, proteins, peptides, nucleic acids
Gene therapy for neurodegenerative disorders in children: dreams and realities.
nucleic acids, mainly DNA, with the aim of treating or curing diseases. This represents a unique therapeutic strategy to reach the brain, in order to prevent or halt a neurodegenerative
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies.
nucleic acids, proteins), and that can have biological functions within and beyond the CNS. Thus, CSF EVs likely serve as both mediators of and contributors to communication
Dual role of exosomes in neurodegenerative diseases: a molecular bridge between neuroinflammation and transmission of pathological proteins.
research due to their complex pathogenesis and the lack of effective treatments. In recent years, extracellular vesicles (EVs), particularly exosomes, have garnered increasing attention for their critical role in cell
New preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry.
nucleic acid metabolism; phospholipase D3 (PLD3) and cathepsin D (CTSD), both related to lysosomal apoptosis; complement component 4 (C4), an element of the classical immune response; and osteopontin (SPP1
Nucleic Acids-Based Biomarkers for Alzheimer's Disease Diagnosis and Novel Molecules to Treat the Disease.
research in this field did not overcome these pitfalls. The tale even worsens when the issue of treating AD is addressed due to the lack of effective strategies despite
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles.
nucleic acids are taken up into lysosomes for degradation. In this review, the current evidence for the function of each LAMP2 isoform in various pathophysiological processes and human diseases
Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon-bone healing.
nucleic acids, such as mRNAs and miRNAs, between cells to influence the physiological and pathological processes of recipient cells. Exosomes have been shown to facilitate tissue repair and regeneration. Herein
Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model.
nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than
Extracellular vesicles: new horizons in neurodegeneration.
nucleic acids, closely linking them to disease onset and progression. Moreover, EVs have emerged as promising diagnostic biomarkers for neurological disorders and as tools for disease staging, owing to their
Molecular and Circulating Biomarkers of Brain Tumors.
nucleic acids, proteins, and tumor-derived extracellular vesicles that accumulate in blood or cerebrospinal fluid. In recent years, circulating tumor cells have also been identified in the blood of glioblastoma
ZBP1: Innate Sensor Regulating Cell Death and Inflammation.
nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypic interaction motif (RHIM) domains for protein homotypic interactions. Recent studies have identified ZBP1