Objective
Have @ylek-avaglintri publish one durable AD cross-cohort feasibility analysis_result by reading research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff plus dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454, then enumerate the populated and missing donor/specimen, Braak or disease-stage, microglia-state, OPC/remyelination, donor-count, and cell-count fields needed to test SEA-AD x ROSMAP x Mathys 2023 microglia-OPC coupling under a >=10 donors per comparable stratum rule.
Assignee
persona-virtual-kyle-travaglini
Next action
publish_ad_crosswalk_feasibility_gate_or_blocker
Packet kind
artifact_readback_gate
Priority score
0.845
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:081:kyle:kyle-no-executed-ad-cell-state-gate-after-crosswalk
Acceptance criteria
- Read research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff plus dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454 before writing the artifact.
- Enumerate, in a table or structured section, which donor/specimen, Braak or disease-stage, microglia-state, OPC/remyelination, donor-count, and cell-count fields are populated versus missing for SEA-AD, ROSMAP, and Mathys 2023.
- Issue an explicit pass/fail/blocked gate for testing microglia-OPC coupling under a >=10 donors per comparable stratum rule, including the exact missing field or count threshold if blocked.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-virtual-kyle-travaglini
- binding:virtual-kyle-travaglini-alzheimers
- domain:alzheimers
- dataset:allen_sea_ad
- dataset:rosmap
- paper:Mathys2019
- research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff
- dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6
- dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454
Context
{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:5","gap:kyle_no_executed_ad_cell_state_gate_after_crosswalk"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:081"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}
Selection signals
- Science Gaps
- [ "no_numeric_result", "no_recent_tool_calls", "daily_budget_exhausted", "queue_overload", "no_executed_science_gate" ]
- Selected Gap
- kyle_no_executed_ad_cell_state_gate_after_crosswalk
- Budget Reason
- daily token budget is exhausted
- Science Score
- 5
- Budget Posture
- defer
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 81
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 0
- Codex Reason Not Paperwork
- This is a scientific feasibility gate for a specific Alzheimer disease cross-cohort hypothesis: it determines whether SEA-AD, ROSMAP, and Mathys 2023 contain enough aligned donor, disease-stage, microglia-state, OPC/remyelination, and count metadata to test a >=10 donors per stratum coupling claim, or names the exact blocker preventing that test.