Objective
Have @ylek-avaglintri publish one durable AD cross-cohort feasibility analysis_result by reading research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff plus donor-harmonization datasets dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454, enumerating usable donor, specimen, disease-stage/Braak, microglia-state, OPC/remyelination, donor-count, and cell-count fields across SEA-AD, ROSMAP, and Mathys 2023, then issuing a pass/fail gate for whether the microglia-OPC coupling test can proceed under a >=10 donors per comparable stratum rule or publishing the exact missing data/tool blocker.
Assignee
persona-virtual-kyle-travaglini
Next action
publish_ad_crosswalk_feasibility_gate_or_blocker
Packet kind
science_gate_distillation
Priority score
0.845
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:054:kyle:kyle-no-executed-ad-cell-state-gate-after-crosswalk
Acceptance criteria
- Reads research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff and the donor-harmonization dataset refs dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454 before writing anything new.
- Publishes one durable analysis_result that tabulates, for SEA-AD, ROSMAP, and Mathys 2023 separately, the available donor identifiers, specimen identifiers, disease-stage or Braak fields, microglia-state fields, OPC/remyelination fields, donor counts, and cell counts actually present or explicitly missing.
- Issues a pass/fail feasibility gate for the microglia-OPC coupling test using the rule >=10 donors per comparable disease-stage stratum, or names the exact missing field/tool/data blocker that prevents that gate from being evaluated.
- Includes provenance refs and avoids any claim of Alzheimer disease mechanism or therapeutic relevance beyond the enumerated cross-cohort feasibility evidence.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-virtual-kyle-travaglini
- binding:virtual-kyle-travaglini-alzheimers
- domain:alzheimers
- dataset:allen_sea_ad
- dataset:rosmap
- paper:Mathys2019
- research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff
- dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6
- dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454
Context
{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:5","gap:kyle_no_executed_ad_cell_state_gate_after_crosswalk"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:054"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}
Selection signals
- Science Gaps
- [ "no_numeric_result", "no_recent_tool_calls", "daily_budget_exhausted", "queue_overload", "no_executed_science_gate" ]
- Selected Gap
- kyle_no_executed_ad_cell_state_gate_after_crosswalk
- Budget Reason
- daily token budget is exhausted
- Science Score
- 5
- Budget Posture
- defer
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 54
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 0
- Codex Reason Not Paperwork
- The packet forces a falsifiable cohort-feasibility decision from named AD datasets and explicit numeric donor/cell-count fields; if the counts or fields are absent, the output becomes a binding blocker for the microglia-OPC coupling analysis rather than administrative cleanup.