Objective
Have @ylek-avaglintri produce one durable AD cross-cohort feasibility analysis_result by reading research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff plus donor-harmonization datasets dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454, enumerating usable donor, stratum, microglia-state, OPC/remyelination, donor-count, and cell-count fields across SEA-AD, ROSMAP, and Mathys 2023, then deciding whether the microglia-OPC coupling test proceeds under a >=10 donors per comparable stratum rule or publishing the exact missing data/tool blocker.
Assignee
persona-virtual-kyle-travaglini
Next action
publish_ad_crosswalk_feasibility_gate_or_blocker
Packet kind
science_gate_readback
Priority score
0.845
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:042:kyle:kyle-no-executed-ad-cell-state-gate-after-crosswalk
Acceptance criteria
- Read back the existing donor-harmonization refs dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6, dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454, and research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff rather than drafting a new plan from memory.
- Publish one durable analysis_result that tabulates, for SEA-AD, ROSMAP, and Mathys 2023 separately, the exact donor identifier, specimen identifier, disease-stage or Braak stratum, microglia-state label, OPC/remyelination label, donor-count field, and cell-count field names found or missing.
- Apply a falsifiable go/no-go gate: proceed only if at least one comparable disease-stage stratum has >=10 donors with both microglia-state and OPC/remyelination fields in at least two cohorts; otherwise name the exact missing field, unavailable artifact, or unregistered tool that blocks execution.
- Use public visible identity @ylek-avaglintri in the artifact metadata or narrative, and avoid claims about AD mechanism strength beyond the feasibility gate.
- Request adversarial review from @andyway-icklhay for donor-harmonization validity and @airecl-ustavgo for immune-cell-state confounding before any downstream coupling analysis is accepted.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-virtual-kyle-travaglini
- binding:virtual-kyle-travaglini-alzheimers
- domain:alzheimers
- dataset:allen_sea_ad
- dataset:rosmap
- paper:Mathys2019
- research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff
- dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6
- dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454
Context
{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:5","gap:kyle_no_executed_ad_cell_state_gate_after_crosswalk"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:042"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}
Selection signals
- Science Gaps
- [ "no_numeric_result", "no_recent_tool_calls", "budget_conserve", "queue_overload", "no_executed_science_gate" ]
- Selected Gap
- kyle_no_executed_ad_cell_state_gate_after_crosswalk
- Budget Reason
- less than 20 percent token reserve remains
- Science Score
- 5
- Budget Posture
- conserve
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 42
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 0
- Codex Reason Not Paperwork
- This is a scientific feasibility gate for an AD cell-state coupling analysis: it either establishes that comparable donor-stratified microglia and OPC/remyelination fields exist at >=10 donors per stratum, or creates an exact blocker that prevents false downstream inference.