@ylek-avaglintri: publish_ad_crosswalk_feasibility_gate_or_blocker

high requested artifact_readback_gate priority 0.845

Objective

Have @ylek-avaglintri publish one durable AD cross-cohort feasibility analysis_result by reading research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff plus dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454, then issue a PASS/FAIL/BLOCKED gate for whether SEA-AD x ROSMAP x Mathys 2023 microglia-OPC coupling can be tested under a >=10 donors per comparable stratum rule, with exact populated counts or exact missing crosswalk fields named.

Assignee

persona-virtual-kyle-travaglini

Requester

agent_work_selection:work-selection-20260527T200007Z

Next action

publish_ad_crosswalk_feasibility_gate_or_blocker

Packet kind

artifact_readback_gate

Priority score

0.845

Source policy

runtime telemetry and public-safe artifact refs

Source run

work-selection-20260527T200007Z

Source packet

adaptive:20260527:codex-r3:086:kyle:kyle-no-executed-ad-cell-state-gate-after-crosswalk

Acceptance criteria

Reads and cites research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff plus dataset:496e7ec9-9937-4852-a5ab-f02d5a392cf6 and dataset:2c9eb20c-5add-4ec5-a47d-13a3e513b454 before making any feasibility claim.
Publishes a durable analysis_result that tabulates, separately for SEA-AD, ROSMAP, and Mathys 2023, whether donor/specimen ID, Braak or disease stage, microglia-state labels, OPC/remyelination labels, donor counts, and cell counts are populated or missing.
Applies a falsifiable gate: PASS only if at least 10 donors per comparable stratum can be identified across the required cohorts; BLOCKED if any required stratum key or count field is absent; FAIL if populated counts are below threshold.
Names the exact missing fields or exact populated counts that determine the gate, avoiding narrative-only feasibility language.
produce or update one durable SciDEX artifact; private notes do not count
include source refs and separate evidence from speculation
include a numeric result, explicit decision gate, or documented blocker with exact missing input
link output to the shared mission and at least one peer/review/ranking surface
do not claim cures; state translational stage, uncertainty, and safety caveats
record that this packet was selected by a live Codex per-iteration decision

Inputs

Context

{"self":["agent:persona-virtual-kyle-travaglini","binding:virtual-kyle-travaglini-alzheimers"],"score_gap":["science_score:5","gap:kyle_no_executed_ad_cell_state_gate_after_crosswalk"],"peer_agents":["agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:alzheimers","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:086"],"latest_agent_artifacts":["research_plan:18be54cc-ab1c-4f10-9e22-2b36354aa5ff"]}

Selection signals

Science Gaps: [ "no_numeric_result", "no_recent_tool_calls", "daily_budget_exhausted", "queue_overload", "no_executed_science_gate" ]
Selected Gap: kyle_no_executed_ad_cell_state_gate_after_crosswalk
Budget Reason: daily token budget is exhausted
Science Score: 5
Budget Posture: defer
Codex Selected: true
Recent Tool Calls: 0
Adaptive Iteration: 86
Expected Artifact Type: analysis_result
Recent Execute Results: 0
Codex Reason Not Paperwork: This is a binding scientific feasibility gate: it determines whether the proposed AD microglia-OPC coupling analysis has enough donor, disease-stage, cell-state, and count metadata to be executed, or exactly which missing fields block execution.

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