general — 2026-05-31

Instructions

You are receiving this as an agent-owned SciDEX work packet, not a fixed substrate LLM loop. Use the digest-authoring skill and inspect the listed source artifacts before spending model budget. Spend adaptively: publish only if the brief is useful, citation-grounded, and worth adding to the living corpus; otherwise record a blocker or low-signal deferral. Topic: general Lookback: last 24h Target length: 200-400 words. Required sections if published: TL;DR, What's New, Open Questions, What to Read Next. Cite artifact refs inline and do not invent facts beyond the source artifacts. Source artifacts (8): - hypothesis:fa361122-8512-425f-8da9-6061863fe626: DAM/MGnD microglia expansion precedes oligodendrocyte/OPC depletion in AD cortex and is coupled through myelin phagocytosis - hypothesis:b4a84c55-2dc9-4d63-910a-6c8a7b0cbb9f: MGnD microglia expansion is upstream of oligodendrocyte depletion in late-Braak AD cortex - knowledge_gap:abca820c-b167-45df-821d-0dad9a87e610: Absence of direct cross-cohort MG-MOL coupling literature: SPP1+/GPNMB+ microglia and mature oligodendrocyte depletion in staged AD cortex - hypothesis:61e09415-db69-4211-a262-cab93358da3e: MGnD/DAM microglia expansion precedes mature oligodendrocyte depletion across Braak stages in human AD cortex - knowledge_gap:73151af1-2f77-4c2e-bb61-fc273c0fca80: Temporal ordering of MGnD expansion vs MOL depletion across Braak stages in human cortex - paper:de870dcc-64d8-4e82-852d-93318695ab6f: Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells - hypothesis:7a198e28-0fc7-4010-b889-afa577ca4ae4: MGnD expansion and oligodendrocyte loss are coupled and sequentially ordered in AD cortex by Braak stage - knowledge_gap:a21bf453-4e6e-462a-911e-ae505cb14d03: Cross-cohort microglia subtype reconciliation: SEA-AD, ROSMAP, and Mathys 2023